28 Clinico Histo-Morphological Spectrum of Endoscopic Biopsies of Upper Gastrointestinal Tract

Abstract

Background: The definitive diagnosis of upper gastrointestinal disorders depends on histopathological
confirmation and is the basis for planning treatment. Aim: To study the spectrum of lesions of upper git
through endoscopic biopsies and determine incidence of H. pylori among gastric lesions through giemsa stain.
Material and Methods:A 2 years prospective study was conducted on upper gastrointestinal tract in a
sample size of 266 endoscopic biopsies from 257 patients. Clinical data was obtained from hospital records
and requisition form submitted along with tissue specimens received in the department and the lesions were
classified based on their clinico-morphological findings. Giemsa stain for H pylori wherever required, was
applied.Results:Endoscopic biopsies were studied on patients ranging from 04 to 97 years with a male to
female ratio of 1.44:1. The most common site of biopsy was Duodenum (36.9%), closely followed by
Stomach (34.9%). The histopathology revealed 80.1% non-neoplastic lesions and 19.9% neoplastic lesions..
H. Pylori was found to be associated with 35.3% cases of chronic gastritis. Conclusion:The key principal of
gastrointestinal biopsy interpretation is correlation with clinical data and endoscopic information in order to
identify the true pathology.