Histomorphological Profile of Non-Infectious Granulomatous Dermatitis: An Appraisal

Abstract

Introduction: Non-infectious granulomatous dermatitis is a distinctive reactive inflammatory condition. Most of these dermatitis is associated with systemic diseases that impact on overall prognosis. Present study aims at classifying the non-infectious granulomatous dermatitis based on morphology of granulomas.
Aims and Objectives: To study the histomorphology of non- infectious granulomatous dermatitis of skin and classify them, accordingly into different categories.
Materials and Methods: It is a descriptive study of 203 cases of non- infectious granulomatous carried over a period of ten years from Jan 2011-Jan 2021. Non-infectious granulomatous dermatitis were diagnosed histopathologically and classified into different types based on morphology, etiology and also compared among different age groups and genders.
Results: Out of total 2,690 skin biopsies received; 314 cases exhibited granulomatous reaction pattern. Among the granulomatous dermatitis, non-infectious granulomas were seen in 203 cases (64.6 %). Among the non-infectious granulomas majority of the cases were foreign body granuloma accounting for 43.3 % followed by interstitial granulomas, Necrobiotic granuloma and sarcoid granuloma in 32.51%, 22.16 % and 1.97 % respectively.
Conclusions: Knowledge of clinical and histomorphology of non-infectious granulomatous dermatitis is very important to understand and diagnosis early and old lesions of dermatitis. Thus, a good clinicopathological correlation in combination with ancillary techniques helps in early and accurate diagnosis.