Clear Cell Myeloma - A Rare Histopathological Variant of a Common Disease

Abstract

Multiple myeloma (MM) is characterized by neoplastic proliferation of plasma cells and monoclonal immunoglobulin production. Clear-cell myeloma is an exceptionally rare histopathological variant of MM, with only ten cases reported worldwide. We present one such case in a 67-year-old female, presenting as a soft tissue osteolytic lesion in the thoracic vertebrae. The final diagnosis was made with the help of histopathological examination, immunohistochemical and hematological features, along with protein electrophoresis and serum free light chain assay. We aim to emphasize its importance as a differential diagnosis for clear cell neoplasms, as timely chemotherapeutic intervention improves the survival rate.