9 Comparative Study Between Propofol-Ketamine and Propofol-Butorphanol For TIVA Techinque in Short Surgical Procedures

Abstract

Background: Total intravenous anaesthesia (TIVA) is a technique in which induction and maintenance
of anaesthesia is achieved with intravenous (IV) drug alone avoiding volatile agents. In this process,
the patient either breaths spontaneously or with bag mask ventilation combined with oxygen. AIMS AND
Objective: To compare Propofol -Ketamine and Propofol -Butorphanol for TIVA in short surgical
procedures in terms of their Hemodynamic stability, Postoperative sedation, Pain on injection with Propofol
& Post operative nausea and vomiting. Material And Methods: This prospective, comparative study was
conducted in 50 patients (18 - 60 years of age), ASA grade I and II, scheduled for elective surgery of duration
less than 1hour. Patients were randomly divided into two groups : Group B-P receive inj.Butorphanol 20 ug/
kg + inj.Propofol 1.5 mg/kg and Group K-P receive inj. Ketamine 1mg/kg + inj. Propofol 1.5 mg/kg and
Anesthesia was maintained with injection Propofol in the dose of 9mg/kg/hour. Results:
Demographic data were comparable between two groups. Both groups were comparable in Hemodynamic
parameters however in Group-BP there was decrease in mean blood pressure which was statistically
insignificant. The incidence of sedation was more in group BP (36%) as compared to group KP (24%) but
difference was statistical insignificant. In group BP, the incidence of pain was 4%, where as in group KP
it was 36 % and this was statistical significant and the incidence of PONV is comparable in both groups.
Conclusion: we concluded that both groups were comparable in terms of their Hemodynamic stability,
Postoperative sedation and PONV but the Pain on injection with Propofol was significantly less in group BP
(p value <0.01)