Correlation of Serum Adiponectin, Ceruloplasmin and C-reactive Protein with Fasting Blood Glucose Levels and Glycosylated Hemoglobin Levels in Type 2 Diabetes

Abstract

Introduction: The correlation of the levels of acute phase reactants ceruloplasmin, C-reactive protein (CRP) and adiponectin with fasting blood glucose (FBG) and glycosylated haemoglobin (HbA1c) were assessed in type 2 diabetes mellitus patients.
Material and Methods: This descriptive cross-sectional study was conducted in Department of Biochemistry, Pathology and Medicine at School of Medical Sciences and Research, Greater Noida. 100 cases of Type II Diabetes mellitus patients with age sex matched controls were included in the study. Blood samples were collected in plain vacutainer for adiponectin, ceruloplasmin, CRP; sodium fluoride vacutainer for plasma blood glucose and EDTA sample for HbA1C. The results thus obtained were analysed statistically by SPSS software version 22.0.
Results: High serum ceruloplasmin and CRP levels were seen in Type 2 diabetic patients. The levels were directly proportional to blood plasma glucose levels and HbA1C. The adiponectin levels are inversely proportional to plasma glucose level and HbA1C in the same group.
Conclusion: There was a significant positive correlation between CRP, ceruloplasmin levels with FBG and HbA1c, while there was inverse correlation of adiponectin with FBG and HbA1c.