Comparative Evaluation of Vildagliptin-Metformin Versus Glimepiride-Metformin on Inflammatory Markers and Glycemic Control in Type 2 Diabetes Mellitus: A Randomized, Open-Label Study

Authors

  • Navreet Kaur
  • Kanav Mehta
  • Sumitpal Singh Chawla

Keywords:

Vildagliptin, Glimepiride, Metformin, Type 2 Diabetes Mellitus, Inflammatory Markers

Abstract

Background: Type 2 Diabetes Mellitus (T2DM) is a chronic disease characterized by the generation of reactive oxygen species, leading to oxidative stress and chronic low-grade inflammation.
Objective: To evaluate the efficacy of the Vildagliptin-Metformin versus the Glimepiride-Metformin combination in reducing inflammatory markers and improving glycemic control in T2DM patients.
Material and Methods: In this randomized, open-label, comparative study, 80 newly diagnosed T2DM patients, above 18 years of age, of either sex, with HbA1c > 6.5% [as per American Diabetes Association (ADA) criteria], were enrolled. They were divided into Group I (Vildagliptin with Metformin) and Group II (Glimepiride with Metformin). Blood samples for biochemical analysis of glycated hemoglobin (HbA1c), fasting blood glucose (FBS), Interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and erythrocyte sedimentation rate (ESR) were collected at baseline and after 12 weeks.
Results: The study found a significant reduction in hs-CRP levels in the Vildagliptin-Metformin group (41.39%) compared to the Glimepiride-Metformin group (15.69%) (p=0.001), indicating a more effective anti-inflammatory effect while maintaining comparable glycemic control.
Conclusion: The Vildagliptin-Metformin combination demonstrated superior efficacy in reducing inflammation in T2DM patients, with glycemic control comparable to the Glimepiride Metformin combination. These findings suggest that Vildagliptin-Metformin could be a more effective therapeutic option for T2DM management, particularly in reducing inflammation.

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Published

10-07-2024

How to Cite

1.
Kaur N, Mehta K, Chawla SS. Comparative Evaluation of Vildagliptin-Metformin Versus Glimepiride-Metformin on Inflammatory Markers and Glycemic Control in Type 2 Diabetes Mellitus: A Randomized, Open-Label Study. JK Science [Internet]. 2024 Jul. 10 [cited 2024 Nov. 13];26(3):160-4. Available from: https://journal.jkscience.org/index.php/JK-Science/article/view/272

Issue

Section

ORIGINAL ARTICLES

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