Schwannoma with Focal Malignant Transformation (MPNST) - A Rare Case Report
Keywords:
MPNST, Schwannoma, Histopathology, Differential diagnosisAbstract
MPNST is a malignant neoplasm commonly arising from a pre-existing nerve sheath tumor in neurofibromatosis type 1 (NF1) or in the setting of prior radiation therapy with an incidence of 0.001% in general population. This case is about a 55-year-old male who was diagnosed with schwannoma in left para-vertebral region extending into posterior mediastinum radiologically, showed a focal malignant transformation histopathologically. Malignant peripheral nerve sheath tumor (MPNST) arising from a schwannoma is an extremely rare entity, so it’s essential for pathologists and surgeons to be aware of the possibility to make accurate diagnosis and choose best treatment options.
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