Efficacy and Safety of Ceftriaxone vs Cefuroxime in Preventing Surgical Site Infection in Patients Undergoing Laparoscopic Cholecystectomy: An Open label, Prospective, Randomized, Comparative Study

Abstract

Background: antimicrobial prophylaxis plays an important role in reducing the rate of SSI, the issue still remains controversial and unanswered in many aspects.
Aim and Objective: the current study was done to assess and compare the efficacy and safety of intravenous Ceftriaxone Vs Cefuroxime in patients undergoing Laparoscopic Cholecystectomy in preventing SSI's.
Method: The present randomized, prospective, open-label, comparative study was done on the patients with USG documented gallstones scheduled for elective Laparoscopic Cholecystectomy. The subjects were divided into two groups. Groups I: I/V single dose ceftriaxone 1g, 30 minutes prior to the incision followed by BD 1g for 2 days postoperatively. Group 2: I/V single dose cefuroxime 1.5g, 30 minutes prior to the incision followed by 1g BD for 2 days post-operatively. To compare the overall incidence of SSI between two groups for first 0 hour, 24 hours, day 7 and week 4 of the surgery, CDC classification for Superficial, deep, organ/space incisional surgical site infection, ASA scale, WHO QOL Scale, Grade of fever, port-site redness/tenderness, wound gape, wound discharge, wound abscess, Hospital stay due to SSI were evaluated and compared between two arms.
Result: The results of the current study thus clearly revealed comparable efficacy and safety of both the drugs and failing to prove any superiority over each other with regards to both primary and secondary endpoint.
Conclusion: The current study revealed comparable efficacy and safety of single dose 30 minutes prior to the incision and followed by twice daily of inj. Ceftriaxone as well as inj. Cefuroxime after surgery for two days in preventing surgical site infection.